Pronunciation: tre-PROST-i-nil
Generic Name: Treprostinil
Brand Name: Remodulin
Treprostinil Solution is used for:
Treating high blood pressure in the blood vessels of the lungs (pulmonary arterial hypertension). It may also be used for other conditions as determined by your doctor.
Treprostinil Solution is a prostaglandin. It works by relaxing blood vessels and increasing the supply of blood to the lungs in patients with high blood pressure in the lungs. This decreases how hard the heart must work to pump blood to the lungs.
Do NOT use Treprostinil Solution if:
- you are allergic to any ingredient in Treprostinil Solution
Contact your doctor or health care provider right away if any of these apply to you.
Before using Treprostinil Solution:
Some medical conditions may interact with Treprostinil Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have liver or kidney problems, bleeding problems, swelling, or high sodium levels in the blood
Some MEDICINES MAY INTERACT with Treprostinil Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Blood pressure medicines (eg, lisinopril), diuretics (eg, furosemide), or vasodilators (eg, hydralazine) because their actions and the risk of their side effects, such as dizziness, fainting, and very low blood pressure, may be increased
- Blood thinners (eg, warfarin) because they may increase the risk of bleeding
- Gemfibrozil because it may increase to risk of Treprostinil Solution's side effects
- Rifampin because it may decrease Treprostinil Solution's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Treprostinil Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Treprostinil Solution:
Use Treprostinil Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Treprostinil Solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Treprostinil Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Treprostinil Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Treprostinil Solution is usually administered as an infusion by direct injection into the skin. It may be necessary for you to take Treprostinil Solution for a prolonged period of time, possibly years. Additional treatment may require injecting medicine through the vein.
- Treprostinil Solution is for injection beneath the skin or through the vein only.
- Do not use Treprostinil Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- If your dose is interrupted, contact your doctor or pharmacist immediately to establish a new dosing schedule.
Ask your health care provider any questions you may have about how to use Treprostinil Solution.
Important safety information:
- Treprostinil Solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Treprostinil Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Stopping Treprostinil Solution, even briefly, may lead to serious side effects. To avoid interruption in medicine treatment you should have access to a backup infusion pump and infusion sets should your equipment fail.
- Depending on your condition, you may be given other medicines to help prevent blood clots. Take all prescribed medicines exactly as directed.
- Treprostinil Solution may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Use Treprostinil Solution with caution in the ELDERLY; they may be more sensitive to its effects.
- Treprostinil Solution should be used with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Treprostinil Solution while you are pregnant. It is not known if Treprostinil Solution is found in breast milk. If you are or will be breast-feeding while you are using Treprostinil Solution, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Treprostinil Solution:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Diarrhea; dizziness; flushing or redness of the skin; headache; jaw pain; joint or muscle aches; lightheadedness; mild pain or redness at the injection site; nausea; pale skin; sweating; tiredness.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; bone or stomach pain; burning, numbness, or tingling; changes in the appearance of the skin (eg, unusual paleness, blue/gray color); chest pain; dark, tarry stools; enlarged abdomen; fainting; fast, slow, or irregular heartbeat; fever; itching; mental or mood changes; pain, swelling, redness, heat, tenderness, or hard skin at the injection site; severe or persistent dizziness; shortness of breath; swelling of the hands, arms, ankles, or feet; unexplained weight gain; unusual bruising or bleeding; unusual fatigue or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Treprostinil side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include fainting; flushing; loss of consciousness; nausea; seizure; severe dizziness, diarrhea, or headache; vomiting.
Proper storage of Treprostinil Solution:
Treprostinil Solution is usually handled and stored by a health care provider. If you are using Treprostinil Solution at home, store Treprostinil Solution as directed by your pharmacist or health care provider. Keep Treprostinil Solution out of the reach of children and away from pets.
General information:
- If you have any questions about Treprostinil Solution, please talk with your doctor, pharmacist, or other health care provider.
- Treprostinil Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Treprostinil Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Treprostinil resources
- Treprostinil Side Effects (in more detail)
- Treprostinil Use in Pregnancy & Breastfeeding
- Treprostinil Drug Interactions
- Treprostinil Support Group
- 4 Reviews for Treprostinil - Add your own review/rating
Compare Treprostinil with other medications
- Pulmonary Arterial Hypertension
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