Generic Name: triptorelin (TRIP toe REL in)
Brand Names: Trelstar Depot, Trelstar Depot Mixject, Trelstar LA, Trelstar LA Mixject
What is Trelstar LA Mixject (triptorelin)?
Triptorelin is a man-made form of a hormone that regulates many processes in the body. Triptorelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.
Triptorelin is used to treat the symptoms of prostate cancer. Triptorelin treats only the symptoms of prostate cancer and does not treat the cancer itself. Use any other medications your doctor has prescribed to best treat your condition.
Triptorelin may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Trelstar LA Mixject (triptorelin)?
You should not use this medication if you are allergic to triptorelin or similar drugs such as leuprolide (Lupron, Viadur, Eligard) or goserelin (Zoladex).
Before using triptorelin, tell your doctor if you have any type of cancer that has spread to your spine, a bladder obstruction or problems with urination, diabetes, heart disease, high blood pressure, high cholesterol, a history of stroke or heart attack, or if you smoke.
After your injection, your prostate cancer symptoms may get worse for a short time because triptorelin raises your testosterone levels. These side effects should get better within 3 or 4 weeks. Call your doctor if your symptoms do not improve, or if they get worse while using triptorelin. Some of the side effects of triptorelin are symptoms of prostate cancer that may occur because the medicine raises your testosterone levels. Call your doctor at once if you have pain or burning when you urinate, blood in your urine, bone pain, numbness, tingling, muscle weakness, or loss of movement in any part of your body. Although triptorelin is not for use by women, this medication can cause birth defects and should not be used by a woman who is pregnant or who may become pregnant.
What should I discuss with my healthcare provider before using Trelstar LA Mixject (triptorelin)?
You should not use this medication if you are allergic to triptorelin or similar drugs such as leuprolide (Lupron, Viadur, Eligard) or goserelin (Zoladex).
If you have any of these other conditions, you may need a triptorelin dose adjustment or special tests:
any type of cancer that has spread to your spine;
a bladder obstruction or problems with urination;
diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol (especially in men);
heart disease, high blood pressure, high cholesterol;
a history of heart attack or stroke; or
if you smoke.
FDA pregnancy category X. Although triptorelin is not for use by women, this medication can harm an unborn baby or cause birth defects. Triptorelin should not be used by a woman who is pregnant or who may become pregnant. It is not known whether triptorelin passes into breast milk or if it could harm a nursing baby. Although triptorelin is not for use by women, this medication should not be used while breast-feeding a baby.
How should I use Trelstar LA Mixject (triptorelin)?
Triptorelin is injected into a muscle. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
This medication comes with a vial (bottle) of powder medicine and a prefilled syringe of sterile water. The powder must be mixed with the sterile water before using the medicine. If you are using the injections at home, be sure you understand how to properly mix and store the medication. Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not save the mixture for later use. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.
Triptorelin is usually given once every 4, 12, or 24 weeks. Your dose schedule will depend on the strength of triptorelin you are using. Follow your doctor's dosing instructions very carefully.
After your injection, your prostate cancer symptoms may get worse for a short time because triptorelin raises your testosterone levels. These side effects should get better within 3 or 4 weeks. Call your doctor if your symptoms do not improve, or if they get worse while using triptorelin.
To be sure this medication is helping your condition, your blood may need to be tested often. Visit your doctor regularly.
Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Store vials and prefilled syringes at room temperature away from moisture, heat, and light. Do not freeze.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of triptorelin.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Trelstar LA Mixject (triptorelin)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Trelstar LA Mixject (triptorelin) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect. Some of these side effects are symptoms of prostate cancer that may occur because the medicine raises your testosterone levels:
painful or difficult urination, burning when you urinate, blood in the urine;
bone pain;
numbness, tingling, or muscle weakness (especially in your legs and feet);
loss of movement in any part of your body;
fever, chills, body aches, flu symptoms;
sudden numbness or weakness, sudden severe headache, confusion, problems with vision or speech; or
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
Less serious side effects may include:
hot flashes;
back pain, pain or swelling in your legs;
headache, dizziness, tired feeling;
decreased interest in sex, impotence, trouble having an orgasm;
nausea, vomiting, diarrhea, upset stomach;
sleep problems (insomnia);
breast pain or swelling; or
pain where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Trelstar LA Mixject (triptorelin)?
There may be other drugs that can interact with triptorelin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Trelstar LA Mixject resources
- Trelstar LA Mixject Side Effects (in more detail)
- Trelstar LA Mixject Use in Pregnancy & Breastfeeding
- Trelstar LA Mixject Drug Interactions
- Trelstar LA Mixject Support Group
- 1 Review for Trelstar LA Mixject - Add your own review/rating
- Trelstar Depot Prescribing Information (FDA)
- Trelstar Depot MedFacts Consumer Leaflet (Wolters Kluwer)
- Trelstar Depot Advanced Consumer (Micromedex) - Includes Dosage Information
- Trelstar LA Prescribing Information (FDA)
- Triptorelin Pamoate Monograph (AHFS DI)
Compare Trelstar LA Mixject with other medications
- Prostate Cancer
Where can I get more information?
- Your doctor or pharmacist can provide more information about triptorelin.
See also: Trelstar LA Mixject side effects (in more detail)
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